Temporal patterning in neural progenitors: from Drosophila development to childhood cancers
نویسندگان
چکیده
منابع مشابه
Temporal patterning of neural progenitors in Drosophila.
Drosophila has recently become a powerful model system to understand the mechanisms of temporal patterning of neural progenitors called neuroblasts (NBs). Two different temporal sequences of transcription factors (TFs) have been found to be sequentially expressed in NBs of two different systems: the Hunchback, Krüppel, Pdm1/Pdm2, Castor, and Grainyhead sequence in the Drosophila ventral nerve c...
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چکیده ندارد.
15 صفحه اولTemporal Patterning in the Drosophila CNS.
A small pool of neural progenitors generates the vast diversity of cell types in the CNS. Spatial patterning specifies progenitor identity, followed by temporal patterning within progenitor lineages to expand neural diversity. Recent work has shown that in Drosophila, all neural progenitors (neuroblasts) sequentially express temporal transcription factors (TTFs) that generate molecular and cell...
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An important question is how dividing stem cells maintain competence to generate multiple cell types, whereas most other cells become progressively restricted during development. The molecular basis for progenitor competence--or how competence is progressively restricted--has remained mysterious. Recent work has shown that Drosophila neuroblasts and mammalian neural progenitors are more similar...
متن کاملNeural progenitors, patterning and ecology in neocortical origins
The anatomical organization of the mammalian neocortex stands out among vertebrates for its laminar and columnar arrangement, featuring vertically oriented, excitatory pyramidal neurons. The evolutionary origin of this structure is discussed here in relation to the brain organization of other amniotes, i.e., the sauropsids (reptiles and birds). Specifically, we address the developmental modific...
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ژورنال
عنوان ژورنال: Disease Models & Mechanisms
سال: 2020
ISSN: 1754-8411,1754-8403
DOI: 10.1242/dmm.044883